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"Put up your dukes." A palm weevil, a type of beetle, looks as though it is spoiling for a fight.Sherif Abdallah Ahmed / Tanta University / Nikon Small World

Photo contest reveals strange beauty of the microscopic world

Nikon's annual Small World competition showcases images of a world that humans can't usually see, as captured through the lens of a microscope.

Each year, rigorous science and dazzling artistry meet in Nikon's Small World photomicrography competition.

Started in 1975, the contest celebrates the beauty of images taken through a light microscope. Scientists and hobbyists alike enter, and the winner receives a $3,000 prize. This year, the competition celebrates its 50th anniversary, and it received about 2,100 photo entries from 80 countries.

If sometimes unnerving, the images are always stunning, and this year's contest is no exception.

1st place

This year's first place prize was awarded to a groundbreaking image of mouse brain tumor cells, taken by Bruno Cisterna, a faculty member at Augusta University's Medical College of Georgia. The photo reveals how disruptions in the cell's cytoskeleton – the structural framework and “highways” known as microtubules – can lead to diseases such as Alzheimer's and amyotrophic lateral sclerosis (better known as ALS or Lou Gehrig’s disease).

Cisterna's research was published in May in the Journal of Cell Biology.

Differentiated mouse brain tumor cells (actin, microtubules, and nuclei)
Bruno Cisterna spent about three months perfecting the staining process to ensure clear visibility of the cells in this image. Bruno Cisterna & Eric Vitriol / Medical College of Georgia at Augusta University / Nikon Small World

2nd place

Second place was awarded to Marcel Clemens, an astronomer turned photographer based in Italy. His image shows an electrical arc between a pin and a wire.

Electrical arc between a pin and a wire
Marcel Clemens (Verona, Italy) / Nikon Small World

3rd place

This image of a cannabis plant leaf, captured by Chris Romaine of Port Townsend, Washington, showcases hairlike plant appendages called trichomes. The bubbles are cannabinoid vesicles — fluid-filled, blisterlike structures.

Leaf of a cannabis plant. The bulbous glands are trichomes. The bubbles inside are cannabinoid vesicles.
Chris Romaine (Port Townsend, Wash.) / Nikon Small World

“Sometimes, we overlook the tiny details of the world around us," said Eric Flem, communications manager at Nikon Instruments. "Nikon Small World serves as a reminder to pause, appreciate the power and beauty of the little things, and to cultivate a deeper curiosity to explore and question.”

Scroll through to see other the highlights of this year's competition:

You say "ladybird," I say "ladybug"

Ladybug
Autofluorescence in the face of a little two-spotted ladybird, the British and Canadian name for a ladybug. Angus Rae / Australian National University / Nikon Small World

Slime mold

Slime mold on a rotten twig with water droplets.
Slime mold on a rotten twig with water droplets.Ferenc Halmos (Hungary) / Nikon Small World

Mosquito larva

Mosquito larva
Anne Patricia Algar (U.K.) / Nikon Small World

So many eyes ...

Green crab spider
Eyes of a green crab spider.Paweł Błachowicz (Poland) / Nikon Small World

Crystals

Recrystallized mixture of hydroquinone and myoinositol
Recrystallized mixture of hydroquinone and myoinositol. Marek Miś Photography (Poland) / Nikon Small World

There’s a wasp in there ...

An insect egg parasitized by a wasp.
An insect egg parasitized by a wasp.Alison K. Pollack (California) / Nikon Small World

Butterfly wings

Wing scales of a butterfly on a medical syringe needle.
Wing scales of a butterfly on a medical syringe needle.Daniel Knop (Germany) / Nikon Small World

Grimace for the camera!

Transverse section of stem of bracken fern.
Transverse section of stem of bracken fern.David Maitland / St. Andrew's / Nikon Small World

Reflective eggs

Golden bug eggs on a sage leaf.
Golden bug eggs on a sage leaf.Jochen Stern (Germany) / Nikon Small World

Water fleas

Two water fleas with embryos, left, and eggs, right.
Two water fleas with embryos, left, and eggs, right.Marek Miś Photography (Poland) / Nikon Small World

Feathery antenna

Antenna of a mole crab
Antenna of a mole crabIgor Robert Siwanowicz / Howard Hughes Medical Institute / Nikon Small World

Hidden world in a grain of sand

Beach sand.
Beach sand.Zhang Chao / Chinese Academy of Sciences / Nikon Small World

Slime mold (Part II)

Slime mold
Focus-stacked composite of 337 exposures at 10x lifesize of a slime mold from California's Eldorado National Forest.Timothy Boomer / WildMacro.com / Nikon Small World

Sea star

Nervous system of a young sea star.
Nervous system of a young sea star.Laurent Formery & Nathaniel Clarke / Stanford University / Nikon Small World